Random Isaac item generator

Tap Generate to get a random item from The Binding of Isaac.

An example, the same for everyone.

Crystal Key

What it does: Clearing a room may open a neighboring red room.

Want a whole run?

Get a character, a boss to beat and one rule for your next run.

Updated September 2026

Press Generate on this Isaac item randomizer for a random item from The Binding of Isaac (TBOI): a game-warping Brimstone, a humble Sad Onion, a Yum Heart, a Curved Horn trinket.

Isaac is about the items you stumble into, so rolling them is half the fun and most of the theorycrafting. Pull three passives and picture how they stack: does Brimstone alongside Polyphemus stay a screen-clearing laser, or do the modifiers fight each other? Some pairings are famous, like the flies a Guppy set builds up, and half the joy is spotting a sleeper combo before you have to play it. Set a build-around challenge where everyone starts forced to make the same rolled item work, or settle an argument about which item is stronger by rolling both.

The filter matches what you want to think about: passives for a stacking puzzle, actives for an on-demand effect you plan a charge around, or trinkets for the small modifiers that change a run at the edges. Leave it on All for the full grab-bag the game throws at you.

Spin the wheel to land one pick live on stream. It is a natural fit for community races: let the draw decide a run's gimmick, or hand everyone the same starting item and see who reads it best. Share a link that carries your filter and count so everyone theorycrafts from the same draw.

The names are real items from the game, text only, so every roll is something you could genuinely find on a run.

Frequently asked questions

What does each item do?

Each result shows a one-line summary of its effect, and the list under the generator carries the same line for every item. The summaries are ours, written for players who want the gist before they pick an item up.

How do I run a build-around challenge?

Roll one item and have everyone start a run forced to build around it, or roll a few passives and theorycraft how the synergies would stack.

Can it randomize a whole run?

Yes. Randomize a run under the generator picks a character, a boss to beat, a difficulty and one rule, and you can swap any one of them.

Can I filter to active, passive, or trinket items?

Yes. The filter narrows the roll to passive items, active items, or trinkets.

Does it include Repentance items?

Yes. The pool holds 892 items and trinkets through Repentance+, Spindown Dice, Abyss and Flip among them. Quest pieces like the Key Pieces and Dad's Note are left out, along with the few items no pool can drop.

Is this the same as an Isaac item randomizer?

Yes. Press Generate for one random item, or roll a handful to randomize a full set for a run.

The full pool, and what each item does

Everything a roll can land on, split into passives, actives and trinkets.

Every item and trinket through Repentance+, minus quest pieces and the two pocket items only one tainted character can hold.

Passive · 538

???'s Only FriendWhat it does: Familiar steered with your fire keys that hurts enemies it touches.
<3What it does: Adds a red heart container and refills all your red hearts.
120 VoltWhat it does: Electric arcs repeatedly zap nearby enemies for light damage.
1up!What it does: Grants an extra life, reviving you at full health in the previous room.
20/20What it does: Double shot.
2SpookyWhat it does: Frightens nearby enemies; fire rate and shot speed up.
3 Dollar BillWhat it does: Tears gain a random effect that changes every 6 seconds.
4.5 VoltWhat it does: Active items charge from damage you deal instead of clearing rooms.
7 SealsWhat it does: Familiar that cycles between Harbingers every ten seconds, each spawning locusts.
8 Inch NailsWhat it does: Damage up, and tears become nails with extra knockback.
9 VoltWhat it does: Fully charges your active on pickup, and actives recharge faster.
A Bar of SoapWhat it does: Fire rate and shot speed up.

Show the other 526 items

A DollarWhat it does: Fills your coin count to the 99 maximum.
A Lump of CoalWhat it does: Tears grow stronger with range.
A Pound of FleshWhat it does: Shops charge health instead of coins, while Devil Deals cost coins.
A QuarterWhat it does: Adds 25 coins.
A SnackWhat it does: Adds a heart container and heals one red heart.
AbaddonWhat it does: Damage and speed up, heart containers become black hearts, tears may frighten enemies.
AbelWhat it does: Familiar mirroring your movement and shooting tears toward you.
Acid BabyWhat it does: Familiar that drops pills; using any pill poisons every enemy in the room.
Act of ContritionWhat it does: Tears up, an Eternal Heart, and Angel Rooms still appear after devil deals.
AdrenalineWhat it does: Damage rises with every empty red heart container.
AkeldamaWhat it does: Leaves a trail of damaging spectral tears behind you in enemy rooms.
Almond MilkWhat it does: Fire rate quadruples, damage falls to 30%, and tears gain random movement effects.
Analog StickWhat it does: Fire rate up and adds diagonal shooting; analog sticks aim freely.
AnemicWhat it does: Range up, and taking damage leaves a red creep trail that hurts enemies.
Angelic PrismWhat it does: Orbiting prism that splits tears passing through it into four.
Angry FlyWhat it does: Fly familiar that circles a random enemy and damages it on contact.
AnkhWhat it does: Grants an extra life, returning you as ??? with three soul hearts.
Anti-GravityWhat it does: Tears hang in place, then fire.
Apple!What it does: Fire rate up, and tears sometimes become razor blades dealing four times damage.
AquariusWhat it does: Your steps leave blue creep that hurts enemies and carries your tear effects.
AriesWhat it does: Speed up, and running into enemies at high speed damages them without hurting you.
Astral ProjectionWhat it does: Taking damage in a fight makes Isaac a flying ghost with spectral tears.
AthameWhat it does: Enemy kills sometimes leave a black ring that rapidly damages nearby enemies.
Azazel's RageWhat it does: After four cleared rooms, entering an enemy room fires a Brimstone laser.
BackstabberWhat it does: Hits from behind deal double damage and make enemies bleed.
Ball of BandagesWhat it does: Orbital that grows with each copy.
Ball of TarWhat it does: Tears sometimes slow enemies, and you leave black creep that slows them too.
Battery PackWhat it does: Recharges your active item and drops two to four batteries.
BBFWhat it does: Familiar that explodes on enemy contact and respawns ten seconds later.
Belly ButtonWhat it does: Adds a second trinket slot and drops a random trinket.
Belly JellyWhat it does: Enemies and some enemy shots bounce off Isaac, and bounced enemies take damage.
Best BudWhat it does: Taking damage spawns an orbiting attack fly for the rest of the room.
BetrayalWhat it does: Enemy shots hurt other enemies, and struck enemies turn on the shooter.
BFFS!What it does: Familiars grow and hit much harder.
Big ChubbyWhat it does: Familiar that charges across the room when you fire, hurting enemies and blocking shots.
Big FanWhat it does: Large orbital that blocks shots and damages enemies on contact.
Binge EaterWhat it does: Heart container and full heal; item pedestals also offer food that permanently boosts stats.
BinkyWhat it does: Grants a soul heart, raises fire rate, and shrinks Isaac.
Bird CageWhat it does: Head-perched bird pounces on the nearest enemy when you take damage.
Bird's EyeWhat it does: Tears sometimes come with a flame that blocks enemy shots and burns enemies.
BirthrightWhat it does: Gives each playable character its own unique upgrade.
Black CandleWhat it does: Blocks curses, grants a black heart, and raises Devil and Angel Room chances.
Black LotusWhat it does: Adds a heart container, a soul heart and a black heart.
Black PowderWhat it does: Leaves a powder trail, and closing a loop with it summons a damaging pentagram.
BlanketWhat it does: Soul heart, one red heart healed, and a one-hit shield in boss rooms.
Blood BagWhat it does: Adds a red heart container, heals 5 hearts and raises speed.
Blood BombsWhat it does: Heart container; bombs leave blood creep and cost health when you have none.
Blood ClotWhat it does: Tears from your left eye deal more damage and travel farther.
Blood OathWhat it does: Drains red hearts on each new floor for a damage and speed boost.
Blood of the MartyrWhat it does: Damage up.
Blood PuppyWhat it does: Familiar that grows stronger with kills, but later hurts you and drops hearts.
Bloodshot EyeWhat it does: Orbiting eye that shoots tears at enemies and blocks incoming shots.
Bloody GustWhat it does: Taking damage stacks speed and fire rate for the floor, up to six times.
Bloody LustWhat it does: Damage climbs as you take hits.
Blue CapWhat it does: Adds a heart container and fires faster, but shot speed drops.
Blue MapWhat it does: Reveals secret rooms on the map.
Bob's BrainWhat it does: Familiar brain you fire at enemies, exploding and poisoning them on impact.
Bob's CurseWhat it does: Grants 5 bombs, and all bombs poison enemies and leave a lingering cloud.
Bobby-BombWhat it does: Bombs home in on enemies.
BOGO BombsWhat it does: Bomb pickups give two bombs instead of one.
Boiled BabyWhat it does: Familiar that sprays tears in random directions, faster when enemies are close.
Bomb BagWhat it does: Familiar that leaves a bomb behind every third room.
Bomber BoyWhat it does: Bombs explode in a cross.
Bone SpursWhat it does: Dying enemies leave floating bones that block enemy shots and damage foes on contact.
Boom!What it does: Adds 10 bombs.
Booster PackWhat it does: Spawns five random cards on pickup.
Bot FlyWhat it does: Orbiting robotic fly that shoots down enemy projectiles and hurts enemies on contact.
BoxWhat it does: Drops one each of coin, key, bomb, heart, card, pill and trinket.
BozoWhat it does: Soul heart, small damage up, and enemies sometimes become charmed or feared.
BreakfastWhat it does: One heart container.
BrimstoneWhat it does: Tears become a charged blood laser that pierces everything in a line.
Brimstone BombsWhat it does: Bombs fire brimstone beams outward.
Brittle BonesWhat it does: Trades red hearts for six bone hearts, which fire a bone ring when lost.
Broken ModemWhat it does: Enemies, shots and pickups freeze briefly at random; room rewards sometimes duplicate.
Broken WatchWhat it does: Every fourth newly found room slows enemies, or rarely speeds them up.
Brother BobbyWhat it does: Familiar that fires tears.
Bucket of LardWhat it does: Adds two red heart containers and lowers speed.
Buddy in a BoxWhat it does: Familiar with random tear effects, fire rate and damage, rerolled each floor.
Bum FriendWhat it does: Familiar trading coins for pickups.
BumboWhat it does: Familiar that grows stronger as it collects coins, gaining drops, tears and contact damage.
Bursting SackWhat it does: Many spider enemies stop targeting you and no longer deal contact damage.
Butt BombsWhat it does: Bombs damage every enemy in the room.
C SectionWhat it does: Tears become homing, piercing, spectral fetuses fired in a short charged burst.
Caffeine PillWhat it does: Raises speed, shrinks Isaac, and gives a random pill.
Cain's Other EyeWhat it does: Familiar that copies your tear effects and fires in random cardinal directions.
Cambion ConceptionWhat it does: Taking enough hits earns up to four permanent demon familiars.
Camo UndiesWhat it does: Each room starts camouflaged, confusing enemies until you fire, then a damage burst.
Candy HeartWhat it does: Healing red hearts gives small random stat boosts; also spawns a red heart.
CapricornWhat it does: Raises most stats, adds a heart container, and grants a coin, bomb and key.
Car BatteryWhat it does: Active items trigger twice each time you use them.
Card ReadingWhat it does: Two portals at floor start lead to boss, treasure, secret, or shop rooms.
Cat-o-nine-tailsWhat it does: Damage up.
Celtic CrossWhat it does: Getting hit sometimes grants a 7-second shield that blocks all damage.
CenserWhat it does: Familiar whose aura slows enemies and enemy shots inside it.
Ceremonial RobesWhat it does: Grants three black hearts and damage up.
Champion BeltWhat it does: Damage up, and champion enemies appear more often.
ChaosWhat it does: Items come from random pools, and picking it up spawns one to six pickups.
Charged BabyWhat it does: Familiar that periodically spawns a battery, charges your active or petrifies enemies.
Charm of the VampireWhat it does: Damage up, and every 13 kills heal half a red heart.
Chemical PeelWhat it does: Left-eye shots deal 2 extra damage.
Chocolate MilkWhat it does: Tears charge; a full charge hits far harder.
Circle of ProtectionWhat it does: A halo hurts enemies inside it and reflects some enemy shots as friendly tears.
Compound FractureWhat it does: Bone tears that shatter into shards.
Cone HeadWhat it does: Adds a soul heart and a 20% chance to negate each hit.
Consolation PrizeWhat it does: Boosts your lowest stat and drops the pickup type you have least of.
ContagionWhat it does: The first kill in each room releases poison gas that spreads between enemies.
ContinuumWhat it does: Tears wrap around the screen edges.
Contract From BelowWhat it does: Room clear rewards double, but a third of clears give nothing.
Crack JacksWhat it does: Adds a heart container and drops a random trinket.
Cracked OrbWhat it does: Taking damage unlocks doors, opens secret rooms and reveals a random room.
Cricket's BodyWhat it does: Tears burst into four smaller tears on impact.
Cricket's HeadWhat it does: Damage up with a 1.5x damage multiplier.
Crown of LightWhat it does: Grants two soul hearts and doubles damage while red hearts are full, until hit.
Cube BabyWhat it does: Ice cube familiar that slides when pushed, slowing enemies it hits and blocking shots.
Cube of MeatWhat it does: Orbital that grows each time you find it.
Cupid's ArrowWhat it does: Tears pierce enemies.
Curse of the TowerWhat it does: Taking damage spawns six troll bombs around the room.
Cursed EyeWhat it does: Charge to fire a burst of tears, but being hit mid-charge teleports you.
Dad's Lost CoinWhat it does: Range up, and a Lucky Penny drops on pickup.
Dad's RingWhat it does: Enemies touching the ring of light around you turn to stone.
Daddy LonglegsWhat it does: Familiar foot that follows you and stomps enemies every few seconds.
Dark BumWhat it does: Familiar trading red hearts for black hearts, pills, cards, runes or spiders.
Dark MatterWhat it does: Damage up, and tears sometimes make enemies flee.
Dark Prince's CrownWhat it does: Fire rate, range and shot speed up while you have exactly one red heart.
Dead BirdWhat it does: Taking damage summons a bird familiar that chases and damages enemies.
Dead CatWhat it does: Nine lives, but health drops to one.
Dead DoveWhat it does: Gives you flight and tears that fly through obstacles.
Dead EyeWhat it does: Damage builds with each consecutive tear hit, and misses can reset it.
Dead OnionWhat it does: Tears pierce enemies and pass over obstacles, with lower range and shot speed.
Dead ToothWhat it does: While you fire, an aura poisons nearby enemies.
Death's ListWhat it does: Enemies get skull marks; clearing them in order grants a random reward.
Death's TouchWhat it does: Piercing scythe tears with a big damage up.
Deep PocketsWhat it does: Raises the coin cap to 999, and empty rooms drop one to three coins.
Demon BabyWhat it does: Auto-fires at anything nearby.
DepressionWhat it does: Familiar that leaves damaging blue creep and rarely calls down holy light.
DessertWhat it does: One heart container.
DinnerWhat it does: One heart container.
Dirty MindWhat it does: Rocks may turn into poop, and breaking poop spawns friendly Dip familiars.
Distant AdmirationWhat it does: Orbiting red fly that deals strong contact damage.
Divine InterventionWhat it does: Double-tapping a fire key raises a brief shield that reflects enemy shots.
Divorce PapersWhat it does: Adds a bone heart and raises fire rate.
Dog ToothWhat it does: Damage and speed up, and a howl warns of nearby undiscovered secret rooms.
Dr. FetusWhat it does: Fires bombs instead of tears.
Dream CatcherWhat it does: Floor transitions reveal the Treasure Room item and boss; half soul heart per floor.
Dry BabyWhat it does: Familiar that blocks shots and sometimes damages every enemy in the room.
DualityWhat it does: Devil and Angel room doors appear together whenever either would spawn.
E. ColiWhat it does: Contact with you turns enemies into poop.
Echo ChamberWhat it does: Using a card, pill or rune also repeats the last three you used.
Eden's BlessingWhat it does: Fires faster, and your next run starts with a random item.
Empty HeartWhat it does: Adds an empty heart container each floor while at one red heart or less.
Empty VesselWhat it does: Grants two black hearts, plus flight and a recurring shield with no red hearts.
Epic FetusWhat it does: Call in a targeted missile strike.
EpiphoraWhat it does: Fire rate ramps up the longer you shoot in one direction.
EucharistWhat it does: Angel Room chance becomes 100% and Devil Rooms stop appearing.
EuthanasiaWhat it does: Sometimes fires needles that instantly kill regular enemies, releasing a ring of tears.
Eve's MascaraWhat it does: Doubles damage, but slows fire rate and shot speed.
Evil CharmWhat it does: Luck up, plus immunity to confusion, fear, burning, and toxic clouds.
Evil EyeWhat it does: Sometimes launches a slow eye that shoots tears in your firing direction.
Experimental TreatmentWhat it does: Four random stats go up and two random stats go down.
ExplosivoWhat it does: Tears sometimes stick to enemies and explode after a moment.
Eye DropsWhat it does: Fire rate up for your left eye, so shots come out staggered.
Eye of BelialWhat it does: Range up; piercing tears gain double damage and homing after passing through an enemy.
Eye of GreedWhat it does: Every 20th tear costs a penny and petrifies enemies, which drop coins if killed.
Eye of the OccultWhat it does: Damage and range up; tears follow your fire keys and hold still otherwise.
Eye SoreWhat it does: Sometimes fires one to three extra tears in random directions.
False PHDWhat it does: Black Heart on pickup; good pills turn bad, and stat-down pills raise damage.
Fanny PackWhat it does: Taking damage has a 50% chance to drop a coin, bomb, key or heart.
Farting BabyWhat it does: Familiar that blocks enemy shots and sometimes farts to charm, poison or repel enemies.
Fast BombsWhat it does: Adds seven bombs and removes the delay between placing bombs.
FateWhat it does: Lets you fly and gives you an eternal heart.
Fate's RewardWhat it does: Familiar firing slowly, with tears carrying your damage and tear effects.
Finger!What it does: Aimable finger familiar firing rapid, invisible spectral lasers.
Fire MindWhat it does: Tears can explode into flames.
Flat StoneWhat it does: Tears bounce along the floor, splashing enemies and flying farther.
Forever AloneWhat it does: Orbiting blue fly that deals light contact damage.
Freezer BabyWhat it does: Familiar firing icicles that turn slain enemies into ice blocks that shatter.
Friend ZoneWhat it does: Fly familiar that slowly orbits you and damages enemies on contact.
Fruit CakeWhat it does: Every shot picks up a random tear effect from a large pool.
Fruity PlumWhat it does: Familiar that moves diagonally toward enemies, firing tears and damaging on contact.
GB BugWhat it does: Familiar launched by double-tapping fire, rerolling the first enemy, trinket or pickup it hits.
GeminiWhat it does: Familiar that chases and damages enemies close to you.
Ghost BabyWhat it does: Familiar firing spectral tears that pass through obstacles.
Ghost BombsWhat it does: Grants five bombs, and detonated bombs release ghosts that chase enemies, then explode.
Ghost PepperWhat it does: Tears sometimes spawn a blue flame that burns enemies and destroys shots.
Giant CellWhat it does: Taking damage spawns a short-lived Minisaac familiar that shoots enemies.
GimpyWhat it does: Taking damage may drop a soul heart, and kills may drop half red hearts.
Glass EyeWhat it does: Damage up and luck up.
GlaucomaWhat it does: Some tears confuse enemies into wandering randomly, and the screen gets darker.
Glitched CrownWhat it does: Item pedestals rapidly cycle between five random items until picked up.
Glitter BombsWhat it does: Adds five bombs, and bombs sometimes drop pickups and charm enemies when they explode.
Glyph of BalanceWhat it does: Adds two soul hearts, and cleared rooms drop whichever pickup you need most.
Gnawed LeafWhat it does: Standing still without shooting for a second turns you into an invulnerable statue.
Goat HeadWhat it does: Guarantees a Devil Room or Angel Room door whenever one can spawn.
God's FleshWhat it does: Tears sometimes shrink enemies so they flee and can be stomped.
GodheadWhat it does: Homing tears with a damaging aura around them.
Greed's GulletWhat it does: Coins become health: one extra heart container per 25 coins, maxing at four.
Growth HormonesWhat it does: Damage and speed up.
Guardian AngelWhat it does: Orbital that blocks enemy shots.
GuillotineWhat it does: Damage up, and your head orbits you, firing tears, blocking shots and hurting enemies.
Guppy's CollarWhat it does: Chance to revive on death.
Guppy's EyeWhat it does: Reveals the contents of chests, grab bags, fireplaces, and shopkeepers.
Guppy's HairballWhat it does: Hairball familiar that stops shots and swings like a flail, growing with kills.
Guppy's TailWhat it does: Room clear rewards sometimes become chests, and sometimes nothing.
HabitWhat it does: Taking damage charges your active item by one room.
HaemolacriaWhat it does: Tears arc and burst into a spread on landing.
Hallowed GroundWhat it does: Familiar that becomes a white poop when hurt, boosting fire rate and blocking hits.
Halo of FliesWhat it does: Two orbiting flies that block shots.
Harlequin BabyWhat it does: Familiar that shoots a pair of tears in a V spread.
Head of the KeeperWhat it does: Tears become coins that sometimes drop a penny where they hit enemies.
Headless BabyWhat it does: Familiar that leaves a trail of red creep damaging ground enemies.
HeartbreakWhat it does: Three broken hearts boost damage, and fatal hits add two more instead of killing.
HemoptysisWhat it does: Double-tapping fire sneezes blood that knocks enemies back and curses them.
Hive MindWhat it does: Blue flies, spiders and locusts grow larger and deal double damage.
Holy GrailWhat it does: Lets you fly and adds a red heart container.
Holy LightWhat it does: Tears sometimes summon a damaging light beam where they hit.
Holy MantleWhat it does: Blocks the first hit in each room.
Holy WaterWhat it does: Bottle familiar that flies where you shoot and leaves a petrifying creep pool.
Host HatWhat it does: Immune to explosions, and sometimes blocks enemy shots and fires three tears back.
Hot BombsWhat it does: Adds five bombs, and explosions leave fire that hurts enemies but not you.
Humbleing BundleWhat it does: Bombs, keys, pennies and red hearts drop as doubles half the time.
Hungry SoulWhat it does: Killing enemies sometimes spawns a friendly ghost that chases foes, then explodes.
HushyWhat it does: Bouncing familiar that hurts enemies on touch and fires tear rings while you shoot.
HypercoagulationWhat it does: Taking damage drops red hearts equal to the damage, which vanish after 1.5 seconds.
IBSWhat it does: Dealing damage charges a random poop attack, used when you release fire.
Immaculate ConceptionWhat it does: Every 15 hearts picked up grants an angelic familiar and a soul heart.
Immaculate HeartWhat it does: Heart container, full heal, 1.2x damage, and extra tears that orbit you.
IncubusWhat it does: Familiar copying your tears at three quarters of your damage.
InfamyWhat it does: Blocks about half of the enemy shots that would hit you.
InfestationWhat it does: Taking damage spawns 2 to 6 blue flies.
Infestation 2What it does: Every enemy killed spawns a friendly blue spider.
Inner ChildWhat it does: Extra life that revives Isaac in place, smaller and faster, with a blood burst.
IpecacWhat it does: Explosive arcing tears that also hurt you up close.
Iron BarWhat it does: Damage up, and tears sometimes confuse enemies.
Isaac's HeartWhat it does: Your body is immune, but hits on your heart familiar damage you instead.
Isaac's TombWhat it does: Spawns a key-locked Old Chest each floor, holding soul hearts, trinkets or items.
It HurtsWhat it does: Taking damage fires a ring of tears and boosts fire rate for the room.
Jacob's LadderWhat it does: Tears spark on impact, and the electricity chains between nearby enemies.
Jaw BoneWhat it does: Familiar that launches across the room when you fire, then returns.
Jesus JuiceWhat it does: Damage up and range up.
Judas' ShadowWhat it does: Dying revives you as Black Judas with two black hearts.
Juicy SackWhat it does: Familiar leaves slowing creep and spawns one or two blue spiders after each room.
Jumper CablesWhat it does: Every 15 kills, your active item gains one charge.
JupiterWhat it does: Two heart containers and poison immunity; standing still builds speed, moving leaves poison clouds.
Keeper's KinWhat it does: Rocks release blue spiders when destroyed and occasionally during fights.
Keeper's SackWhat it does: Drops coins and a key, and every three coins spent adds a stat boost.
Key BumWhat it does: Familiar trading keys for chests.
Kidney StoneWhat it does: Periodically forces a charged piercing stone shot, then a rapid, inaccurate tear spray.
King BabyWhat it does: Leads your familiars and holds them in place while you fire.
Knockout DropsWhat it does: Tears sometimes turn into fists that knock enemies back hard and confuse them.
LachryphagyWhat it does: Tears decelerate and burst into several tears when they stop or hit obstacles.
Large ZitWhat it does: Sometimes fires an extra tear that slows enemies and leaves white creep.
Latch KeyWhat it does: Gives a soul heart and two keys, and raises luck.
Lazarus' RagsWhat it does: Revives you in place as Lazarus Risen with Anemic and permanent damage up.
Lead PencilWhat it does: Every 15th shot fires a short-range burst of twelve tears at once.
LeechWhat it does: Familiar leech that attacks enemies and heals you a half heart per kill.
LeoWhat it does: Walking into rocks breaks them, and you grow larger.
LeprosyWhat it does: Taking damage adds an orbiting body part that blocks shots and hurts enemies.
LibraWhat it does: Evens out damage, range, fire rate and speed, plus six coins, bombs and keys.
Lil AbaddonWhat it does: Familiar that charges while you shoot, then makes a damaging black ring.
Lil BrimstoneWhat it does: Familiar firing a brimstone laser.
Lil ChestWhat it does: Familiar chest that sometimes drops a pickup or trinket when a room clears.
Lil DeliriumWhat it does: Familiar that swaps into a different random familiar every ten seconds.
Lil DumpyWhat it does: Familiar that farts before you get hit, pushing away enemies and shots.
Lil GurdyWhat it does: Familiar that charges up and launches itself at enemies, bouncing off walls.
Lil HauntWhat it does: Familiar ghost that chases enemies, damaging and frightening them.
Lil LokiWhat it does: Familiar firing tears in all four cardinal directions at once.
Lil MonstroWhat it does: Familiar that charges up and fires a cluster of tears.
Lil PortalWhat it does: Familiar that launches forward when you shoot, turning pickups it touches into blue flies.
Lil SpewerWhat it does: Familiar that spits creep; using a pill changes the creep type.
Linger BeanWhat it does: Firing nonstop for several seconds creates a brown cloud that damages enemies inside.
Little BaggyWhat it does: Holds a second pill, and card drops turn into pills.
Little C.H.A.D.What it does: Familiar that drops half hearts.
Little ChubbyWhat it does: Charger familiar that rushes across the room when you shoot, damaging enemies.
Little GishWhat it does: Familiar firing slowing black tears.
Little HornWhat it does: Tears sometimes summon a hand that instantly kills regular enemies; touching enemies hurts them.
Little StevenWhat it does: Familiar with homing tears.
LodestoneWhat it does: Some tears magnetize enemies, drawing in nearby enemies, pickups, and all shots.
Loki's HornsWhat it does: Chance to fire tears in all four directions at once.
Lord of the PitWhat it does: Lets you fly and raises speed.
Lost ContactWhat it does: Tears block enemy shots.
Lost FlyWhat it does: Fly familiar that latches onto obstacles, damages enemies and distracts them from you.
Lost SoulWhat it does: Fragile ghost familiar; surviving a floor earns hearts or an item.
Lucky FootWhat it does: Luck up, better pill and drop odds.
LunaWhat it does: Adds extra secret rooms; their light beams grant tears up and soul hearts.
LunchWhat it does: One heart container.
Lusty BloodWhat it does: Damage climbs as you kill enemies.
Maggy's BowWhat it does: Adds a heart container, and red hearts restore twice as much.
Magic 8 BallWhat it does: Raises shot speed, spawns a random tarot card and improves Planetarium odds.
Magic MushroomWhat it does: Damage, speed and range up, plus a heart container and full heal.
Magic ScabWhat it does: Adds a heart container and luck up.
MagnetoWhat it does: Draws pickups in toward you.
MarblesWhat it does: Spawns three trinkets; taking damage may permanently swallow the trinket you hold.
MarkedWhat it does: Shoots automatically at a crosshair you steer, plus fire rate and range up.
MarrowWhat it does: Adds a bone heart and drops three red hearts.
MarsWhat it does: Double-tap a direction to dash.
Match BookWhat it does: Gives a black heart and drops three bombs.
Maw of the VoidWhat it does: Holding fire charges a black brimstone ring that bursts around you on release.
MEAT!What it does: Damage up and a heart container.
Member CardWhat it does: A trapdoor in each shop leads to an underground shop with more goods.
MercuriusWhat it does: Speed up, and room doors open even while enemies are alive.
Metal PlateWhat it does: Grants a soul heart and sometimes reflects enemy shots back as homing tears.
Midas' TouchWhat it does: Touching enemies petrifies them in gold and damages them based on your coins.
Midnight SnackWhat it does: Adds a red heart container and heals one extra heart.
Milk!What it does: Glass familiar that blocks shots, then shatters after ten hits to raise fire rate.
Mini MushWhat it does: Raises speed and range and shrinks you.
Missing No.What it does: Rerolls your passive items and randomly adjusts stats on pickup and each new floor.
Missing Page 2What it does: Grants a black heart, and dropping to one heart or less triggers Necronomicon.
MitreWhat it does: Red heart pickups sometimes become soul, black or bone hearts instead.
Mom's Coin PurseWhat it does: Drops four random pills next to you.
Mom's ContactsWhat it does: Raises range, and tears sometimes petrify enemies.
Mom's EyeWhat it does: Chance to fire an extra tear backwards.
Mom's EyeshadowWhat it does: Tears sometimes charm enemies.
Mom's HeelsWhat it does: Range up.
Mom's KeyWhat it does: Grants two keys, and chests drop double coins, keys, bombs and hearts.
Mom's KnifeWhat it does: Replaces tears with a knife you charge and throw.
Mom's LipstickWhat it does: Raises range and spawns a red heart on pickup.
Mom's PearlsWhat it does: Grants a soul heart and raises luck and range.
Mom's PerfumeWhat it does: Fires faster, and tears sometimes frighten enemies.
Mom's PurseWhat it does: Lets you hold a second trinket, and spawns a random trinket.
Mom's RazorWhat it does: Orbiting razor that damages enemies, makes them bleed and blocks shots.
Mom's RingWhat it does: Damage up, plus a random rune or soul stone on pickup.
Mom's UnderwearWhat it does: Raises range and spawns 3 to 6 blue flies on pickup.
Mom's WigWhat it does: Chance to spawn friendly spiders.
Money = PowerWhat it does: Each coin you hold adds a little damage.
Mongo BabyWhat it does: Familiar that copies the shots of your other familiars in turn.
MonstranceWhat it does: Damage aura around you that hits harder the closer enemies stand.
Monstro's LungWhat it does: Charge up and release a shotgun spray of tears.
Montezuma's RevengeWhat it does: Stopping after a few seconds of continuous fire blasts a brown laser behind Isaac.
More OptionsWhat it does: Treasure rooms offer a choice of two items instead of one.
Mr. DollyWhat it does: Fires faster with more range, and drops three random hearts.
Mr. MegaWhat it does: Much larger bomb blasts.
MucormycosisWhat it does: Sometimes fires spores that stick to enemies, then burst and poison nearby foes.
Multidimensional BabyWhat it does: Familiar that splits tears passing through it into two faster, longer-range parallel tears.
Mutant SpiderWhat it does: Four tears per shot, with a much slower fire rate.
My ReflectionWhat it does: Tears boomerang back to you.
My ShadowWhat it does: Shadow familiar that spawns a friendly Charger whenever an enemy touches it.
Mysterious LiquidWhat it does: Tears leave damaging creep.
Mystery EggWhat it does: Egg familiar that hatches into a friendly monster when you take damage.
Mystery SackWhat it does: Familiar dropping a random pickup.
Nancy BombsWhat it does: Five bombs, and placed bombs take on random bomb effects.
NeptunusWhat it does: Not firing stores tears that fire in a rapid burst when you shoot.
Night LightWhat it does: Casts a cone of light that slows enemies and their shots.
No. 2What it does: Holding fire for about two seconds drops a free Butt Bomb.
Number OneWhat it does: Fires much faster, short range.
Obsessed FanWhat it does: Fly familiar that trails your movement with a delay, damaging enemies on contact.
Ocular RiftWhat it does: Tears sometimes open a damaging rift that pulls in enemies, pickups and shots.
Odd Mushroom (Large)What it does: Adds a heart container, with damage and range up and speed down.
Odd Mushroom (Thin)What it does: Fire rate and speed up, damage down, and you shrink.
Old BandageWhat it does: Adds an empty heart container, and taking damage may drop a red heart.
Options?What it does: Room clear rewards come with a second option; taking one removes the other.
Orphan SocksWhat it does: Speed up, two soul hearts, and immunity to spikes and creep.
Ouija BoardWhat it does: Tears pass through obstacles and fire slightly faster.
Pageant BoyWhat it does: Seven coins drop around you, plus a random penny trinket.
Papa FlyWhat it does: Fly familiar that trails you and shoots at nearby enemies every second.
ParasitoidWhat it does: Some tears become egg sacks that spawn blue flies or spiders.
Paschal CandleWhat it does: Familiar candle that stacks fire rate for rooms cleared without taking damage.
Pay to PlayWhat it does: Adds five coins; locked doors and chests need a penny instead of a key.
PentagramWhat it does: Damage up, and Devil or Angel Room doors appear more often.
PHDWhat it does: Identifies pills, turns bad ones good, spawns a pill and heals two red hearts.
Piggy BankWhat it does: Drops coins when you take damage.
PiscesWhat it does: Fires faster, with larger tears that knock enemies back harder.
PJsWhat it does: Grants four soul hearts and fully heals you.
PlacentaWhat it does: Heart container and slow regeneration.
Playdough CookieWhat it does: Tears take on random colors, each with its own effect.
PlutoWhat it does: Tears up; you shrink, fitting through gaps and letting some shots pass overhead.
Pointy RibWhat it does: Bone familiar you aim with the fire buttons, hurting enemies it touches.
Poke GoWhat it does: Entering an enemy room has a 20% chance to spawn a friendly monster.
PolydactylyWhat it does: Holds two cards or pills at once and spawns a random one.
PolyphemusWhat it does: One huge slow tear that carries damage through the enemy it kills.
Pop!What it does: Tears turn into eyeballs with unlimited range that ricochet off one another.
ProptosisWhat it does: Tears start huge and shrink as they travel.
Psy FlyWhat it does: Fly familiar that chases and blocks enemy shots, damaging enemies on contact.
Punching BagWhat it does: Familiar decoy that attracts enemy attacks and blocks enemy shots.
Pupula DuplexWhat it does: Tears grow bigger and pass through obstacles.
PurgatoryWhat it does: Enemy rooms get a red crack; stepping on it summons a homing, exploding ghost.
PurityWhat it does: A random aura boosts damage, fire rate, speed or range until you are hit.
PyroWhat it does: Adds 99 bombs.
PyromaniacWhat it does: Explosions heal you instead of hurting.
QuintsWhat it does: Kills spawn random baby familiars that stay in the room, up to five.
Rainbow BabyWhat it does: Familiar firing random tear effects.
Raw LiverWhat it does: Two heart containers and a full heal.
Red StewWhat it does: Full heal and a large damage boost that decays over time; kills extend it.
RedemptionWhat it does: Entering a Devil Room and taking nothing earns a soul heart and damage up.
RestockWhat it does: Buying from a shop restocks it, with prices rising each time.
RevelationWhat it does: Flight; holding fire for about two seconds and releasing shoots a holy laser.
Robo-BabyWhat it does: Familiar firing a small laser.
Robo-Baby 2.0What it does: Steerable familiar firing lasers.
Rock BottomWhat it does: Stats never drop below the highest values they have reached.
Rocket in a JarWhat it does: Five bombs; placing a bomb while firing launches it as a rocket.
Roid RageWhat it does: Raises speed and range.
RosaryWhat it does: Fire rate up and three soul hearts.
Rotten BabyWhat it does: Familiar that spawns friendly blue flies while you hold fire in rooms with enemies.
Rotten MeatWhat it does: One heart container.
Rotten TomatoWhat it does: Tears sometimes bait enemies, slowing them and making other enemies attack them.
Rubber CementWhat it does: Tears bounce off walls.
Rune BagWhat it does: Familiar dropping runes.
Sack HeadWhat it does: Spawns a grab bag, and pickups sometimes turn into grab bags.
Sack of PenniesWhat it does: Familiar dropping a coin every two rooms.
Sack of SacksWhat it does: Familiar that drops a Grab Bag every few rooms.
Sacred HeartWhat it does: Full heal, large damage up, and strongly homing tears.
Sacred OrbWhat it does: Rerolls low-quality items on pedestals, so better items appear.
Sacrificial DaggerWhat it does: Orbiting dagger that blocks shots and deals heavy contact damage.
Sad BombsWhat it does: Bombs fire tears in every direction.
Safety PinWhat it does: Gives a black heart, with range and shot speed up.
SagittariusWhat it does: Speed up, and tears pierce through enemies.
SalvationWhat it does: Halo around Isaac that strikes enemies inside it, growing when you take damage.
Samson's ChainsWhat it does: Drags a ball and chain that damages enemies, blocks shots and smashes rocks.
Sanguine BondWhat it does: Adds Devil Room spikes that cost a heart and give a random reward.
SaturnusWhat it does: Ring of orbiting tears damages enemies and catches enemy shots.
SausageWhat it does: Heart container, full heal, all stats up, plus better Devil, Angel and Planetarium odds.
ScapularWhat it does: Reaching your last half heart grants a soul heart, once per room.
Scatter BombsWhat it does: Bombs split into several smaller ones.
SchoolbagWhat it does: Adds a second active item slot and lets you swap between them.
ScorpioWhat it does: Tears poison enemies, dealing damage over time.
ScrewWhat it does: Fires faster, and tears fly faster.
SeraphimWhat it does: Angel familiar firing strong homing tears.
Serpent's KissWhat it does: Tears sometimes poison, and touching enemies poisons them and may drop black hearts.
ShadeWhat it does: Shadow familiar that damages enemies on touch, then merges into you for contact damage.
Shard of GlassWhat it does: Hits make you bleed, spraying blood tears until healed, and may drop red hearts.
Sharp PlugWhat it does: Trades health for a full recharge of your active item.
Sinus InfectionWhat it does: Some tears become boogers that stick to enemies and deal damage over time.
Sissy LonglegsWhat it does: Wandering familiar that spawns blue spiders and briefly charms enemies it touches.
Sister MaggyWhat it does: Familiar that fires strong tears.
SkatoleWhat it does: Most fly enemies become passive, slower or less damaging.
Skeleton KeyWhat it does: Adds 99 keys.
Slipped RibWhat it does: Orbiting bone that reflects enemy shots back at them.
Smart FlyWhat it does: Familiar fly that blocks shots and chases enemies after you take a hit.
SMB Super FanWhat it does: Heart container and full heal, plus damage, fire rate, speed and range up.
SolWhat it does: Shows the boss room; killing a boss boosts damage and luck and recharges actives.
Soul LocketWhat it does: Spawns a soul heart, and soul or black hearts gained give random stat boosts.
Soy MilkWhat it does: Enormous fire rate, tiny damage per tear.
Spear of DestinyWhat it does: Spear familiar aimed where you last shot, damaging enemies and scaring bosses.
Speed BallWhat it does: Raises speed and shot speed.
Spelunker HatWhat it does: Reveals nearby room types, secret rooms included, and blocks falling projectiles.
Spider BiteWhat it does: Chance for tears to slow enemies and their projectiles.
Spider ModWhat it does: Spider familiar that reveals enemy health bars and inflicts random status effects.
SpiderbabyWhat it does: Taking damage spawns two to five friendly blue spiders.
Spirit of the NightWhat it does: Lets you fly, and tears pass through obstacles.
Spirit ShacklesWhat it does: A fatal hit turns you into a ghost; surviving ten seconds revives you.
Spirit SwordWhat it does: Replaces tears with a swinging sword that shoots beams at full health.
Spoon BenderWhat it does: Tears home in on enemies.
SqueezyWhat it does: Fires faster and spawns two soul hearts.
StaplerWhat it does: Damage up, but tears fire only from the right eye.
Star of BethlehemWhat it does: Star that drifts to the boss room; its aura boosts damage and fire rate.
Starter DeckWhat it does: Holds a second card or rune, and pill drops turn into cards.
Steam SaleWhat it does: Shop items cost half as much.
Stem CellsWhat it does: Adds a red heart container, heals a heart and raises shot speed.
StevenWhat it does: Small damage up.
Sticky BombsWhat it does: Adds five bombs, and bombs stick to enemies and spawn blue spiders.
StigmataWhat it does: Damage up and a heart container.
Stop WatchWhat it does: Speed up, and enemies, enemy shots and your tears all move slower.
Strange AttractorWhat it does: Tears attract enemies, pickups and trinkets like a magnet.
StrawmanWhat it does: Adds Keeper as a second controllable character; his death spawns blue spiders.
StyeWhat it does: Right-eye tears gain damage and range but lose shot speed.
SuccubusWhat it does: Familiar with a dark aura that hurts enemies and boosts your damage inside it.
Sulfuric AcidWhat it does: Damage up; some tears destroy obstacles and open doors, secret rooms included.
Super BandageWhat it does: Adds a filled red heart container and two soul hearts.
SupperWhat it does: One heart container.
Sworn ProtectorWhat it does: Orbital familiar that blocks shots and may drop an eternal heart after ten blocks.
SynthoilWhat it does: Raises damage and range.
Tarot ClothWhat it does: Drops a random tarot card, and many tarot cards gain extra effects.
TaurusWhat it does: Starts slow, speeds up during fights, then turns invincible briefly at top speed.
Tech XWhat it does: Tears become chargeable laser rings that pass through enemies and obstacles.
Tech.5What it does: Sometimes fires a piercing laser along with your tears.
TechnologyWhat it does: Tears become a piercing red laser.
Technology 2What it does: Adds a constant thin laser alongside weaker tears.
Technology ZeroWhat it does: Electric arcs link your tears together and damage enemies they cross.
TerraWhat it does: Damage up; tears turn into rocks that knock back enemies and break obstacles.
The BatteryWhat it does: Active items can bank one additional use beyond a full charge.
The BeltWhat it does: Speed up.
The Black BeanWhat it does: Taking damage makes you fart five times, poisoning and repelling nearby enemies.
The BodyWhat it does: Grants three extra red heart containers.
The Common ColdWhat it does: Chance for tears to poison enemies.
The CompassWhat it does: Reveals special rooms on the map.
The HaloWhat it does: Small boosts to damage, fire rate, speed and range, plus a heart container.
The Inner EyeWhat it does: Triple shot, slower fire rate.
The IntruderWhat it does: Head-dwelling spider fires slowing tears; taking damage may release it as a familiar.
The LadderWhat it does: Places a ladder over one-tile gaps, letting you walk across.
The Ludovico TechniqueWhat it does: One floating tear you steer around the room.
The MarkWhat it does: Adds a black heart and raises damage and speed.
The MindWhat it does: Full map with every secret marked.
The MulliganWhat it does: Tears occasionally release allied blue flies on hitting enemies.
The PactWhat it does: Adds two black hearts and raises damage and fire rate.
The ParasiteWhat it does: On impact, each tear divides into two weaker tears.
The PeeperWhat it does: Familiar eye that blocks shots and damages enemies; left-eye tears deal 35% more.
The RelicWhat it does: Familiar that drops a soul heart every 7 or 8 rooms.
The Sad OnionWhat it does: Fires faster.
The Small RockWhat it does: Damage up, slightly slower.
The SoulWhat it does: Two soul hearts and an aura that pushes enemies and shots away.
The StairwayWhat it does: Every floor starts with a ladder to an Angel Room shop.
The SwarmWhat it does: Grants eight orbiting flies, one more for each cleared room, up to sixteen.
The VirusWhat it does: Raises speed, and enemies that touch you are poisoned, sometimes dropping black hearts.
The WaferWhat it does: Nearly all hits cost you at most half a heart.
The WizWhat it does: Fires two spectral tears diagonally outward from both eyes.
There's OptionsWhat it does: Boss rewards give a choice of two items.
Thunder ThighsWhat it does: Adds a heart container, lowers speed, and walking into rocks breaks them.
Tiny PlanetWhat it does: Range up, and your spectral tears orbit around you until they land.
TinytomaWhat it does: Orbital familiar that blocks shots, splits when hit, and spawns blue spiders.
TMTRAINERWhat it does: All future items become glitched, with randomly combined effects.
Tooth and NailWhat it does: Every six seconds you briefly turn to spiked stone, immune and damaging on touch.
Tooth PicksWhat it does: Fire rate and shot speed up.
Torn PhotoWhat it does: Fire rate and shot speed up.
Tough LoveWhat it does: Chance to fire a tooth that deals heavy damage.
Toxic ShockWhat it does: Poisons every enemy in a room when you enter it.
Tractor BeamWhat it does: Tears travel along a beam that tracks your facing direction, even as you turn.
TranscendenceWhat it does: Lets you fly.
Treasure MapWhat it does: Reveals the whole floor layout.
Trinity ShieldWhat it does: A shield that blocks enemy shots faces the direction you fire.
TrisagionWhat it does: Tears become short piercing beams of light.
TropicamideWhat it does: Range up and larger tears.
Twisted PairWhat it does: Two familiars copying your tears.
UranusWhat it does: Ice tears that freeze enemies.
Vanishing TwinWhat it does: Familiar that becomes a boss clone in boss rooms, dropping an extra boss item.
Varicose VeinsWhat it does: Taking damage fires a ring of ten tears with bonus damage.
VasculitisWhat it does: Killed enemies burst into blood clot tears, more for tougher enemies.
Vengeful SpiritWhat it does: Taking damage spawns a wisp that shoots tears for the floor, up to six.
VenusWhat it does: Heart container and heal; enemies near you are charmed.
VirgoWhat it does: Taking damage may grant a ten second shield, and bad pills turn good.
Voodoo HeadWhat it does: Adds an extra Curse Room each floor, with better layouts and a guaranteed coin.
Whore of BabylonWhat it does: Large damage and speed up while on half a heart.
Wire Coat HangerWhat it does: Fires faster.
Wooden SpoonWhat it does: Speed up.
Worm FriendWhat it does: Familiar that restrains an enemy in place for four seconds, dealing damage.
X-Ray VisionWhat it does: Uncovers and opens every secret and super secret room entrance.
YO LISTEN!What it does: Luck up; a familiar flies toward hidden rooms, tinted rocks, and crawl spaces.
ZodiacWhat it does: Each floor grants a different random zodiac sign effect.

Active · 166

A PonyWhat it does: Flight, plus an invincible forward dash that damages enemies.
AbyssWhat it does: Destroys pedestal items in the room, spawning a locust familiar for each.
Alabaster BoxWhat it does: Charged by soul hearts; single use spawns soul hearts and two Angel Room items.
Anarchist CookbookWhat it does: Spawns troll bombs around the room.
Anima SolaWhat it does: Chains the nearest enemy in place for five seconds.
Bag of CraftingWhat it does: Grinds eight pickups into an item.
Berserk!What it does: Melee frenzy with a swinging weapon.
Best FriendWhat it does: Drops a decoy that draws enemy attention, then explodes after 5 seconds.
Black HoleWhat it does: Throws a black hole that pulls in enemies and shots for several seconds.
Blank CardWhat it does: Uses your held card without spending it.
Blood RightsWhat it does: Costs a heart, and every enemy in the room takes 40 damage.
Bob's Rotten HeadWhat it does: Hurls a poison bomb in one direction, exploding on impact.

Show the other 154 items

Book of RevelationsWhat it does: Soul heart and a shot at a horseman.
Book of SecretsWhat it does: Adds a random Treasure Map, Compass or Blue Map effect until the floor ends.
Book of ShadowsWhat it does: Brief invincibility.
Book of the DeadWhat it does: Summons orbiting bones or friendly skeletons for each enemy killed in the room.
Book of VirtuesWhat it does: Spawns wisps that fight for you.
Box of FriendsWhat it does: Duplicates your familiars for the room, or adds a Demon Baby if none.
Box of SpidersWhat it does: Releases friendly blue spiders.
Breath of LifeWhat it does: Hold to drain the charge, then become invincible while you keep holding.
Brown NuggetWhat it does: Spawns a stationary fly turret that shoots nearby enemies.
Butter BeanWhat it does: Fart knocks back nearby enemies and deflects enemy shots.
Clear RuneWhat it does: Uses your held rune without spending it.
ClickerWhat it does: Turns you into a random character, with a chance to remove your last item.
CompostWhat it does: Room pickups become blue flies or spiders, and it doubles those you have.
ConverterWhat it does: Swaps one soul or black heart for a filled red heart container.
CouponWhat it does: Makes one priced item free; while held, one shop item is half price.
Crack the SkyWhat it does: Calls down five light beams that heavily damage enemies they touch.
Crooked PennyWhat it does: Coin flip: double your pickups or lose them.
Crystal BallWhat it does: Maps the floor and drops a soul heart or card; improves Planetarium odds.
D InfinityWhat it does: Acts as any dice item except Spindown Dice; cycle them with the drop key.
D1What it does: Duplicates a random pickup in the room.
D10What it does: Replaces every enemy in the room with a weaker one.
D100What it does: Rerolls the room and everything you hold.
D12What it does: Rerolls the obstacles in the room.
D20What it does: Rerolls every pickup in the room.
D4What it does: Rerolls all of your collected items.
D7What it does: Resets the room, bringing back all its monsters, with clear rewards paid again.
D8What it does: Rerolls your damage, fire rate, range and speed.
Dad's KeyWhat it does: Opens every door in the room.
DamoclesWhat it does: Doubles item pedestals with a lethal catch.
Dark ArtsWhat it does: Brief speed boost and invulnerability, freezing and damaging enemies and shots you pass through.
DataminerWhat it does: Glitches the room: one stat rises, another falls, and tears gain random effects.
Dead Sea ScrollsWhat it does: Runs the effect of a randomly chosen active item from a preset list.
Death CertificateWhat it does: Teleports you to a room of nearly every unlocked item; taking one returns you.
Decap AttackWhat it does: Throws Isaac's head, which shoots tears and blocks shots until retrieved.
Deck of CardsWhat it does: Produces a random card.
DeliriousWhat it does: Summons a friendly boss to fight for you.
DiplopiaWhat it does: Duplicates every pickup and item pedestal in the room, then is consumed.
Doctor's RemoteWhat it does: Shows a steerable crosshair, then a missile hits that spot for heavy damage.
Dull RazorWhat it does: Simulates taking a hit without losing health, triggering on-damage items.
Eden's SoulWhat it does: Spawns two items from the current room pool, then vanishes.
EraserWhat it does: Throws an eraser that removes an enemy and blocks its return for the run.
Esau Jr.What it does: Swaps you with Esau Jr., a flying character with three black hearts.
Eternal D6What it does: Rerolls every item pedestal in the room; each has a chance to vanish.
Everything JarWhat it does: Spawns pickups based on its charge, and a full charge triggers random effects.
FlipWhat it does: Swaps each pedestal item with a ghost item behind it, letting you take both.
Flush!What it does: Non-boss enemies become poop, the room floods, and fires go out.
Forget Me NowWhat it does: Remakes the current floor with a fresh layout, then disappears.
Fortune CookieWhat it does: Gives a fortune, or rarely a soul heart, card, rune or trinket.
Free LemonadeWhat it does: Drops a pool of lemonade creep that damages enemies.
Friend FinderWhat it does: Spawns a random friendly monster that mirrors your movement and attacks until it dies.
Friendly BallWhat it does: Captures a non-boss enemy when thrown, then releases it as a lasting ally.
GelloWhat it does: Spawns a demon familiar for the room that lunges and shoots as you fire.
GenesisWhat it does: Removes all items, then offers three choices from the pool of each lost item.
Glass CannonWhat it does: Fires one huge piercing shot; a hit breaks it and drains two extra hearts.
Glowing HourglassWhat it does: Rewinds to the previous room.
Golden RazorWhat it does: Spends five coins for extra damage in the current room; stacks with reuse.
Guppy's HeadWhat it does: Spawns a swarm of blue flies.
Guppy's PawWhat it does: Converts a red heart into soul hearts.
Head of KrampusWhat it does: Fires a Brimstone laser in each of the four cardinal directions.
How to JumpWhat it does: Jump over gaps and obstacles.
Isaac's TearsWhat it does: Fires eight tears in a ring, and firing tears recharges it.
IV BagWhat it does: Each use costs some health and yields one or two coins.
Jar of FliesWhat it does: Stores flies from kills and releases them.
Jar of WispsWhat it does: Spawns orbiting wisps, one more each time it is used.
Kamikaze!What it does: Explodes on your own position.
Keeper's BoxWhat it does: Spawns a random shop pickup or item that costs coins.
Kidney BeanWhat it does: Releases a fart that charms all nearby enemies.
LarynxWhat it does: Shout that damages and pushes back enemies and clears shots; taking damage charges it.
LemegetonWhat it does: Spawns an orbiting wisp that blocks shots and carries a random item's effect.
Lemon MishapWhat it does: Spills a puddle of damaging creep.
Magic FingersWhat it does: Costs one coin per use and damages every enemy in the room.
Magic SkinWhat it does: Trades a heart container for an item from the current room pool.
Mama Mega!What it does: Single use: destroys obstacles and deals 200 damage in every room this floor.
Meat CleaverWhat it does: Splits every enemy in the room into two weaker copies.
Mega BeanWhat it does: Petrifies all enemies, poisons nearby ones, and creates a huge damaging explosion.
Mega BlastWhat it does: A huge brimstone beam you steer.
Mega MushWhat it does: Become giant with enormous damage.
MetronomeWhat it does: Borrows a random item effect for the current room.
Mine CrafterWhat it does: Spawns a movable TNT block that explodes when you use the item again.
Mom's Bottle of PillsWhat it does: Produces a random pill.
Mom's BoxWhat it does: Luck up and doubled trinket effects while held; using it drops a random trinket.
Mom's BraWhat it does: Turns every enemy in the room to stone for four seconds.
Mom's BraceletWhat it does: Lifts obstacles in front of you and throws them at enemies.
Mom's PadWhat it does: Frightens every enemy in the room.
Monster ManualWhat it does: Summons a random familiar that lasts the rest of the floor.
Monstro's ToothWhat it does: Calls in Monstro to crash onto a random enemy for heavy damage.
Moving BoxWhat it does: Packs up pickups and carries them along.
Mr. BoomWhat it does: Drops one oversized bomb.
Mr. ME!What it does: A ghost fetches pickups, opens chests, or attacks whatever your crosshair targets.
My Little UnicornWhat it does: Invincible and damaging on contact.
Mystery GiftWhat it does: Single use: spawns a random item from the room pool, sometimes coal or poop.
Notched AxeWhat it does: Swaps tears for a melee axe that breaks obstacles and damages enemies.
Pandora's BoxWhat it does: Consumed on use, spawning pickups or items that depend on the current floor.
PauseWhat it does: Freezes enemies where they stand.
PlaceboWhat it does: Uses your held pill without spending it.
Plan CWhat it does: Kills everything, then kills you.
Plum FluteWhat it does: Summons Baby Plum to fight for you for about ten seconds.
Portable SlotWhat it does: Spends a coin per use for a chance at a random pickup.
Potato PeelerWhat it does: Trade a heart container for damage.
Prayer CardWhat it does: Yields an eternal heart.
R KeyWhat it does: Sends you back to the first floor while keeping every item and pickup.
Razor BladeWhat it does: Costs a full heart for a damage boost lasting the room.
Red CandleWhat it does: Throws a flame that lingers.
Red KeyWhat it does: Opens a door to a new Red Room beside the current room.
Remote DetonatorWhat it does: Adds 5 bombs, and your bombs detonate only when you use it.
Sacrificial AltarWhat it does: Single use: sacrifices up to two familiars, spawning an item for each.
Satanic BibleWhat it does: Gives a black heart and swaps the boss item for a devil deal.
ScissorsWhat it does: Your head becomes a stationary turret for the room while your body keeps shooting.
Sharp KeyWhat it does: Five keys; thrown keys pierce enemies, open locks, and kills may drop chest loot.
Sharp StrawWhat it does: Hurts every enemy in the room and may drop half hearts.
Shoop da Whoop!What it does: Fires one big laser from your face.
SmelterWhat it does: Consumes held trinkets and applies their effects permanently.
Spider ButtWhat it does: Damages and slows every enemy in the room; kills spawn blue spiders.
Spin to WinWhat it does: Grants a shot-blocking orbital; using it adds speed and boosts familiar damage.
Spindown DiceWhat it does: Steps items down to the previous ID.
SprinklerWhat it does: Places a stationary sprinkler that spins and fires tears in eight directions.
StitchesWhat it does: Swaps places with a familiar you steer by shooting, damaging enemies you land on.
SulfurWhat it does: Tears become a Brimstone blood laser for the room; repeat uses add damage.
SumptoriumWhat it does: Spends half a heart for a clot familiar that copies your movement and shots.
Suplex!What it does: Dashes forward, grabs an enemy, then leaps and slams down for damage.
Tammy's HeadWhat it does: Fires a ring of tears outward.
Tear DetonatorWhat it does: Splits every tear in the air into six tears flying outward.
TelekinesisWhat it does: Holds nearby enemy shots in place for three seconds, then sends them back.
Telepathy For DummiesWhat it does: Homing tears for the room.
Teleport 2.0What it does: Teleports you into an unexplored room, favoring ordinary rooms over special ones.
Teleport!What it does: Teleports you to a random room.
The BeanWhat it does: Releases a poison fart that damages nearby enemies and deflects projectiles.
The BibleWhat it does: Flight for the room.
The Book of BelialWhat it does: Big damage up for the room.
The Book of SinWhat it does: Creates one random pickup: coin, heart, bomb, key, battery, pill or card.
The BoomerangWhat it does: Throws a boomerang that damages and petrifies enemies and retrieves pickups.
The CandleWhat it does: Throws a blue flame.
The D6What it does: Rerolls every item in the room.
The GamekidWhat it does: Briefly makes you invulnerable, scaring enemies and damaging those you touch.
The HourglassWhat it does: Slows every enemy in the room.
The JarWhat it does: Holds up to four red hearts picked up at full health; use drops them.
The NailWhat it does: Black heart, damage up, and you break rocks.
The NecronomiconWhat it does: Damages every enemy in the room.
The Pinking ShearsWhat it does: Detaches your body for the room to fight enemies while your head flies.
The PoopWhat it does: Drops a pile of poop.
The ScooperWhat it does: Summons a Peeper for the room that hurts enemies and blocks enemy shots.
UndefinedWhat it does: Teleports you to a special room.
Unicorn StumpWhat it does: Six seconds of invulnerability and extra speed, but you cannot shoot.
Urn of SoulsWhat it does: Sprays blue flames that hurt enemies and destroy shots; kills charge it.
Vade RetroWhat it does: Slain enemies leave red ghosts; using it detonates them, hurting enemies and clearing shots.
Ventricle RazorWhat it does: Places linked blue and orange portals that teleport you between them.
VoidWhat it does: Absorbs items in the room for permanent stats.
Wait What?What it does: Knocks back enemies and their shots, then sends out a damaging rock wave.
Wavy CapWhat it does: Each use gives a fading fire rate boost and speed penalty.
We Need to Go Deeper!What it does: Makes a trapdoor that leads to the next floor.
White PonyWhat it does: Flight, plus an invincible forward dash that creates damaging light beams.
Wooden NickelWhat it does: Chance to produce a coin.
Yuck HeartWhat it does: Fills a red or bone heart container with a rotten heart.
Yum HeartWhat it does: Heals one heart.

Trinket · 188

???'s SoulWhat it does: Familiar that drifts in a zigzag, firing spectral homing tears.
'MWhat it does: Using your active item rerolls it into a different one.
A LighterWhat it does: Entering a room may set its enemies on fire.
A Missing PageWhat it does: Getting hit sometimes damages every enemy in the room.
AAA BatteryWhat it does: Active item charges one step sooner.
Ace of SpadesWhat it does: Cards and runes drop more often.
Adoption PapersWhat it does: Shops and Black Markets sell 10-coin familiars instead of their usual items.
Apollyon's Best FriendWhat it does: Locust familiar flying forward while you shoot, damaging enemies on contact.
Apple of SodomWhat it does: Red heart pickups sometimes turn into blue spiders instead of healing.
Azazel's StumpWhat it does: Clearing a room may give Azazel's short brimstone tears, flight and 1.5x damage.
Baby-BenderWhat it does: Familiar shots home in on enemies.
Bag LunchWhat it does: Taking damage sometimes breaks it and spawns Lunch, which adds a heart container.

Show the other 176 items

Bat WingWhat it does: Kills sometimes grant flight for the rest of the room.
Beth's EssenceWhat it does: Entering an Angel Room spawns five wisps; beggar donations may add more.
Beth's FaithWhat it does: Spawns four tear-firing wisps that orbit you at the start of each floor.
Bible TractWhat it does: Eternal hearts drop more often.
Black FeatherWhat it does: Damage up for each evil item or trinket you hold.
Black LipstickWhat it does: Black hearts drop more often.
Black ToothWhat it does: Tears sometimes become poisonous black teeth that deal double damage.
Blasting CapWhat it does: Exploding bombs have a chance to drop a bomb pickup.
Blessed PennyWhat it does: Picking up coins sometimes drops a half soul heart.
Blind RageWhat it does: Doubles invincibility time after taking damage.
BlisterWhat it does: Tears knock enemies back harder.
Bloody CrownWhat it does: Treasure rooms appear on the Womb, Utero, Scarred Womb and Corpse floors.
Bloody PennyWhat it does: Coins can drop half a red heart.
Blue KeyWhat it does: Locked doors open free but lead through a blue enemy room first.
Bob's BladderWhat it does: Bombs leave damaging green creep.
Brain WormWhat it does: Tears turn 90 degrees toward enemies they pass.
Broken AnkhWhat it does: Dying has a chance to revive you as ??? in the previous room.
Broken GlassesWhat it does: Treasure rooms may add a second, hidden item; taking one item removes the other.
Broken MagnetWhat it does: Pulls coins toward you.
Broken PadlockWhat it does: Explosions unlock locked doors and chests and break key blocks.
Broken RemoteWhat it does: Using an active item also teleports you to a random room.
Broken SyringeWhat it does: Entering a room may give a random syringe item's effect until you leave.
Brown CapWhat it does: Destroyed poops explode like small bombs.
Burnt PennyWhat it does: Coins can drop a bomb.
Butt PennyWhat it does: Picking up coins triggers a knockback fart, and poops may drop extra coins.
Butter!What it does: Using an active item drops it; taking damage sometimes drops a passive item.
Cain's EyeWhat it does: Each new floor has a chance of granting the Compass effect.
CallusWhat it does: Immune to spikes and floor creep.
CancerWhat it does: Fire rate up.
CartridgeWhat it does: Taking damage has a luck-based chance to trigger the Gamekid effect.
Charged PennyWhat it does: Picking up coins sometimes adds a charge to your active item.
Chewed PenWhat it does: Tears sometimes slow the enemies they hit.
Child LeashWhat it does: Familiars stay closer to you and get 25% more damage and size.
Child's HeartWhat it does: Hearts drop more often.
Counterfeit PennyWhat it does: Picking up a coin sometimes grants one bonus coin.
Cracked CrownWhat it does: Stat boosts to speed, range, shot speed, damage and tears grow 20%.
Cracked DiceWhat it does: Taking damage has a 50% chance to trigger a random dice item effect.
Cricket LegWhat it does: Killing an enemy has a 1 in 6 chance to spawn a random locust.
Crow HeartWhat it does: Red hearts absorb damage before soul, black and rotten hearts.
Crystal KeyWhat it does: Clearing a room may open a neighboring red room.
Cursed PennyWhat it does: Each coin pickup teleports you to a random room, influenced by coin type.
Cursed SkullWhat it does: Teleports you away at low health.
Curved HornWhat it does: Damage up.
Daemon's TailWhat it does: Most heart drops become keys, and the remaining hearts are black hearts.
Devil's CrownWhat it does: Treasure rooms offer devil deal items for the usual health cost.
Dice BagWhat it does: Entering a room may give a one-use die that vanishes when you leave.
Dim BulbWhat it does: Stats up while your active is empty.
Dingle BerryWhat it does: Clearing a room spawns a random friendly dip.
Door StopWhat it does: The door you entered through stays open, letting you leave mid-fight.
Duct TapeWhat it does: Familiars keep a fixed position relative to you as you move.
Endless NamelessWhat it does: Using a card or pill sometimes drops another copy.
Equality!What it does: Fires faster while coins, bombs and keys are all equal.
ErrorWhat it does: Gives the effect of a random trinket in each room.
Eve's Bird FootWhat it does: Killed enemies can spawn a Dead Bird familiar for the room.
Expansion PackWhat it does: Using an active item also triggers a random low-charge active item.
Extension CordWhat it does: Electric arcs link you and your familiars, damaging enemies between them.
Faded PolaroidWhat it does: Now and then you fade out, confusing every enemy in the room.
Filigree FeatherWhat it does: Defeated angels drop an Angel Room item instead of a key piece.
Finger BoneWhat it does: Taking damage sometimes grants a bone heart.
Fish HeadWhat it does: Getting hit releases one or two blue flies.
Fish TailWhat it does: Doubles the blue flies and locusts that other items spawn.
Flat FileWhat it does: All spikes retract and stop dealing damage.
Flat PennyWhat it does: Coins can drop a key.
Flat WormWhat it does: Tears are 50 percent wider with slightly more knockback.
Forgotten LullabyWhat it does: Familiars fire twice as fast.
Found SoulWhat it does: Ghost familiar copies your movement and fires spectral tears at half your damage.
Fragmented CardWhat it does: Adds one extra secret room to every floor you enter.
Friendship NecklaceWhat it does: Familiars orbit you instead of trailing behind.
Gigante BeanWhat it does: Farts from Butter Bean and similar items have a larger radius.
Gilded KeyWhat it does: New chests become golden chests holding an item or several pickups.
Goat HoofWhat it does: Speed up.
Golden Horse ShoeWhat it does: Treasure Rooms more often offer two items, and you take one.
HairpinWhat it does: Fully recharges your active item on first entering a boss room.
Hollow HeartWhat it does: Grants a bone heart at the start of each floor.
Holy CrownWhat it does: The Cathedral gets a treasure room and a shop.
Hook WormWhat it does: Tears travel in a zigzag.
Ice CubeWhat it does: Entering a room may petrify each enemy for four seconds, freezing them on death.
Isaac's ForkWhat it does: Clearing a room has a luck-based chance to heal half a red heart.
Isaac's HeadWhat it does: Familiar head that follows Isaac and fires piercing tears.
JawbreakerWhat it does: Some shots become teeth dealing 3.2 times your damage.
Judas' TongueWhat it does: Red heart Devil deals cost only one heart container.
KarmaWhat it does: Donating can heal you, refund the penny, spawn a beggar or raise luck.
Keeper's BargainWhat it does: Devil deal items may cost coins instead, 15 per heart container.
Kid's DrawingWhat it does: Counts as one of the three items needed for the Guppy transformation.
Lazy WormWhat it does: Damage up, shot speed down.
Liberty CapWhat it does: Random mushroom item effect.
Lil ClotWhat it does: Clot familiar copies your movement and shots, and respawns in the next room.
Lil LarvaWhat it does: Each poop you destroy releases a blue fly.
Locust of ConquestWhat it does: Entering a room with enemies spawns one to four white locusts.
Locust of DeathWhat it does: Entering a room with enemies spawns a black locust dealing quadruple damage.
Locust of FamineWhat it does: Entering a room with enemies spawns a yellow locust that slows foes.
Locust of PestilenceWhat it does: Entering a room with enemies spawns a green locust that poisons foes.
Locust of WarWhat it does: Entering a room with enemies spawns a red locust that explodes on impact.
Lost CorkWhat it does: Creep left by you, your familiars and allies spreads wider.
LouseWhat it does: Spawns a blue spider in uncleared rooms after a delay.
Lucky RockWhat it does: About a third of broken rocks drop a penny.
Lucky SackWhat it does: A Grab Bag pickup spawns each time you reach a new floor.
Lucky ToeWhat it does: Luck up and a chance of extra pickups from chests, tinted rocks and machines.
Maggy's FaithWhat it does: Grants an eternal heart at the start of each floor.
Match StickWhat it does: Bombs drop more often.
MeconiumWhat it does: Poops may turn black, and black poops can drop black hearts.
Missing PosterWhat it does: Revives you as The Lost on death, and may reveal a Super Secret Room.
Modeling ClayWhat it does: Entering a room may copy a random passive item's effect from its pool.
Mom's LockWhat it does: Each room has a chance to grant a random passive Mom item's effect.
Mom's LocketWhat it does: Unlocking with keys grants half a red heart; half-heart pickups become full hearts.
Mom's PearlWhat it does: Heart drops sometimes become soul, black or bone hearts.
Mom's ToenailWhat it does: In fights, Mom's foot stomps a random spot every 20 seconds, hurting anything there.
Monkey PawWhat it does: Hits that leave half a heart or less drop a black heart, three uses.
Mother's KissWhat it does: Grants an extra heart container while held.
MyosotisWhat it does: Up to four pickups left behind reappear in the next floor's start room.
Mysterious CandyWhat it does: Isaac may fart or poop every 30 seconds, and farts damage enemies.
Mysterious PaperWhat it does: Cycles between four paper effects.
NO!What it does: Stops active items from appearing in item pools while held.
Nose GoblinWhat it does: Chance to fire a sticky homing tear.
Nuh Uh!What it does: From Chapter 4 on, coin and key drops turn into other random pickups.
Number MagnetWhat it does: Adds 10% devil room chance; devil rooms gain black hearts and enemies.
Old CapacitorWhat it does: Clearing rooms no longer charges actives but often drops a Lil' Battery.
Ouroboros WormWhat it does: Tears fly in a large spiral, with range and fire rate up.
Panic ButtonWhat it does: Uses your active item automatically just before you take a hit.
Paper ClipWhat it does: Opens locked chests without using keys.
Pay to WinWhat it does: A restock machine always spawns in treasure rooms.
PerfectionWhat it does: Huge luck up, lost the moment you take a hit.
Petrified PoopWhat it does: Poop drops pickups more often.
Pinky EyeWhat it does: Chance to fire a poison tear.
Poker ChipWhat it does: Each chest is a coin flip between extra loot and just an Attack Fly.
Polished BoneWhat it does: Clearing a room sometimes spawns a friendly Bony.
Pulse WormWhat it does: Tears pulse between sizes as they fly.
Purple HeartWhat it does: More enemies spawn as champions.
Push PinWhat it does: Chance to fire piercing, spectral tears.
Rainbow WormWhat it does: Tears cycle through worm trinket effects every three seconds.
RC RemoteWhat it does: Familiars are steered by your movement inputs instead of following you.
Red PatchWhat it does: Taking damage has a luck-based chance to add 1.8 damage for the room.
Rib of GreedWhat it does: Cleared rooms drop coins more often and hearts less often.
Ring CapWhat it does: Each bomb you place drops a second bomb for free.
Ring WormWhat it does: Tears corkscrew in a fast, steady spiral; fire rate up.
Rosary BeadWhat it does: Angel rooms take the place of devil rooms.
Rotten PennyWhat it does: Picking up a coin spawns a blue fly.
Rusted KeyWhat it does: Keys drop more often.
Safety CapWhat it does: Pills drop more often.
Safety ScissorsWhat it does: Troll bombs turn into normal bomb pickups before exploding.
Samson's LockWhat it does: Enemy kills can grant a damage boost that lasts the room.
Second HandWhat it does: Status effects last longer on enemies.
Shiny RockWhat it does: Tinted rocks and rocks hiding crawl spaces flash periodically.
Short FuseWhat it does: Placed bombs explode in 0.66 seconds and deal extra damage.
Sigil of BaphometWhat it does: Each kill grants a second of invincibility, stacking up to five seconds.
Silver DollarWhat it does: Shops appear on the Womb, Utero, Scarred Womb and Corpse floors.
Stem CellWhat it does: Restores half your missing red hearts when you reach a new floor.
Store CreditWhat it does: Shop items cost nothing, but the trinket is used up after one purchase.
Store KeyWhat it does: The shop is always unlocked.
Strange KeyWhat it does: Opens the Blue Womb passage no matter how long your run has lasted.
Stud FinderWhat it does: Breaking rocks has a small chance to spawn a crawl space.
Super BallWhat it does: Chance for tears to bounce.
Super MagnetWhat it does: Pulls pickups and enemies toward Isaac.
Swallowed M80What it does: Taking damage has a 50% chance to set off a 185 damage explosion.
Swallowed PennyWhat it does: Drops a coin when you take damage.
Tape WormWhat it does: Range up.
Teardrop CharmWhat it does: Luck-based tear effects trigger more often, worth four extra luck.
Telescope LensWhat it does: Planetariums spawn far more often and can appear in Chapter 4 and Corpse.
Temporary TattooWhat it does: Clearing challenge rooms drops a chest; boss challenges drop an extra boss item.
The Left HandWhat it does: Every chest becomes a red chest.
The TwinsWhat it does: Entering a room may duplicate a familiar; with none, it adds Bobby or Maggy.
TickWhat it does: Drains health from bosses; cannot be dropped.
TonsilWhat it does: Repeated hits taken summon a shot-blocking tonsil familiar, twice at most.
Torn CardWhat it does: Every 15th shot is a boomerang tear that explodes and poisons on impact.
Torn PocketWhat it does: Taking damage spills two random coins, bombs or keys.
Umbilical CordWhat it does: Spawns a helper when you drop low.
Used DiaperWhat it does: Entering combat rooms spawns a blue fly and may neutralize enemy flies.
Vibrant BulbWhat it does: Stats up while your active is charged.
WalnutWhat it does: Explosion hits may break it, dropping a coin, heart, key and trinket.
Watch BatteryWhat it does: Batteries drop more often.
Whip WormWhat it does: Tears fly noticeably faster.
Wicked CrownWhat it does: Sheol gets a treasure room and a shop.
Wiggle WormWhat it does: Fire rate up and wavy tears.
Wish BoneWhat it does: Taking damage sometimes breaks it and drops an item from the room's pool.
Wooden CrossWhat it does: Grants a shield that blocks one hit per floor.
Your SoulWhat it does: Pays for one devil deal item instead of hearts, then disappears.

Item names match The Binding of Isaac: Repentance+, and the effect lines are ours, checked against the Binding of Isaac wiki, last checked September 29, 2026.

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